Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice - can it explain the behavioral regression in Autism?

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Title: Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice - can it explain the behavioral regression in Autism?
Authors: Qiao SN; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Wang SE; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Pharmacology, Hallym University College of Medicine, 1 Hallymdaehak-gil, Chuncheon-si, Gangwon-do, South Korea., Kim KY; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Jo S; Department of Biology, Soonchunhyang University, Soonchunhyang-ro 22, Sinchang-myeon, Asan, South Korea., Jiang YH; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Wu-Tsai Institute, Yale University, 100 College Street, New Haven, CT, 06520, USA. yong-hui.jiang@yale.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4369-4385. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Qiao+SN%22">Qiao SN</searchLink>; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SE%22">Wang SE</searchLink>; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Pharmacology, Hallym University College of Medicine, 1 Hallymdaehak-gil, Chuncheon-si, Gangwon-do, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+KY%22">Kim KY</searchLink>; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Jo+S%22">Jo S</searchLink>; Department of Biology, Soonchunhyang University, Soonchunhyang-ro 22, Sinchang-myeon, Asan, South Korea.<br /><searchLink fieldCode="AU" term="%22Jiang+YH%22">Jiang YH</searchLink>; Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.; Wu-Tsai Institute, Yale University, 100 College Street, New Haven, CT, 06520, USA. yong-hui.jiang@yale.edu.
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        Value: 10.1038/s41380-026-03534-2
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        Text: English
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      – TitleFull: Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice - can it explain the behavioral regression in Autism?
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            NameFull: Qiao SN
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            NameFull: Kim KY
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              Text: 2026 Aug
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              Y: 2026
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