Cellular senescence in skeletal muscle: myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities.

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Title: Cellular senescence in skeletal muscle: myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities.
Authors: Papanikolaou K; Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States., Yadav A; Department of Cell Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States., Mankowski RT; Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States., Alexander MS; Division of Neurology, Department of Pediatrics, University of Alabama at Birmingham and Children's of Alabama, Birmingham, Alabama, United States.; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States., Gamboa JL; Division of Nephrology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States., Thalacker-Mercer AE; Department of Cell Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.; Birmingham Department of Veterans Affairs, Birmingham, Alabama, United States., Dungan CM; Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, United States., Englund DA; Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 May 01; Vol. 330 (5), pp. C1148-C1171. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1522-1563
DOI:10.1152/ajpcell.00876.2025