Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study.
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| Title: | Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study. |
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| Authors: | de Graaf H; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Gbesemete DF; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Hill AR; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Fröberg J; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Ibrahim MM; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Dale AP; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Laver JR; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Gorringe AR; UK Health Security Agency, Porton Down, Salisbury, UK., Faust SN; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Kester KE; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA., Buisman AM; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA., Berbers GAM; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands., Brummelman J; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands., van Els CACM; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., Eleveld MJ; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands., Diavatopoulos DA; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Read RC; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: r.c.read@soton.ac.uk. |
| Source: | The Lancet. Microbe [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101313. Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41887240 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22de+Graaf+H%22">de Graaf H</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Gbesemete+DF%22">Gbesemete DF</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Hill+AR%22">Hill AR</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Fröberg+J%22">Fröberg J</searchLink>; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ibrahim+MM%22">Ibrahim MM</searchLink>; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Dale+AP%22">Dale AP</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Laver+JR%22">Laver JR</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Gorringe+AR%22">Gorringe AR</searchLink>; UK Health Security Agency, Porton Down, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Kester+KE%22">Kester KE</searchLink>; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Buisman+AM%22">Buisman AM</searchLink>; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Berbers+GAM%22">Berbers GAM</searchLink>; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Brummelman+J%22">Brummelman J</searchLink>; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Els+CACM%22">van Els CACM</searchLink>; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Eleveld+MJ%22">Eleveld MJ</searchLink>; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Diavatopoulos+DA%22">Diavatopoulos DA</searchLink>; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Read+RC%22">Read RC</searchLink>; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: r.c.read@soton.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101313. <i>Date of Electronic Publication: </i>2026 Mar 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101769019 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-5247 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226665247%22">26665247 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Microbe <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41887240 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lanmic.2025.101313 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 101313 Titles: – TitleFull: Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de Graaf H – PersonEntity: Name: NameFull: Gbesemete DF – PersonEntity: Name: NameFull: Hill AR – PersonEntity: Name: NameFull: Fröberg J – PersonEntity: Name: NameFull: Ibrahim MM – PersonEntity: Name: NameFull: Dale AP – PersonEntity: Name: NameFull: Laver JR – PersonEntity: Name: NameFull: Gorringe AR – PersonEntity: Name: NameFull: Faust SN – PersonEntity: Name: NameFull: Kester KE – PersonEntity: Name: NameFull: Buisman AM – PersonEntity: Name: NameFull: Berbers GAM – PersonEntity: Name: NameFull: Brummelman J – PersonEntity: Name: NameFull: van Els CACM – PersonEntity: Name: NameFull: Eleveld MJ – PersonEntity: Name: NameFull: Diavatopoulos DA – PersonEntity: Name: NameFull: Read RC IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2666-5247 Numbering: – Type: volume Value: 7 – Type: issue Value: 4 Titles: – TitleFull: The Lancet. Microbe Type: main |
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