Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study.
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| Title: | Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study. |
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| Authors: | de Graaf H; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Gbesemete DF; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Hill AR; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Fröberg J; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Ibrahim MM; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Dale AP; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Laver JR; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK., Gorringe AR; UK Health Security Agency, Porton Down, Salisbury, UK., Faust SN; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Kester KE; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA., Buisman AM; Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA., Berbers GAM; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands., Brummelman J; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands., van Els CACM; Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., Eleveld MJ; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands., Diavatopoulos DA; Radboud Community for Infectious Diseases, Radboud UMC, Nijmegen, Netherlands; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, Netherlands., Read RC; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Controlled Human Infection Group, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: r.c.read@soton.ac.uk. |
| Source: | The Lancet. Microbe [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101313. Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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