PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion.
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| Title: | PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion. |
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| Authors: | Celada L; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.; Fundación Idonial, Gijón, Spain., Cubiella T; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., San-Juan-Guardado J; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Suárez-Priede Á; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Gómez-Suárez N; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Salerno L; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Murias E; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain., Da Silva Torres M; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain., Weiner JA; Department of Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA., Herrada-Manchón H; Fundación Idonial, Gijón, Spain., Fernández MA; Fundación Idonial, Gijón, Spain., Chiara MD; Health Research Institute of the Principado de Asturias, Oviedo, Spain. mdchiara.uo@uniovi.es.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain. mdchiara.uo@uniovi.es. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Mar 26; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08643-y |
