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Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer.

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Title: Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer.
Authors: Raack EJ; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Chang WC; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Cordova-Delgado M; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Anderson SJ; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Trueman JN; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Scott EN; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Loucks CM; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Rassekh SR; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Groeneweg GSS; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Higginson M; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Li K; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Miao F; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Yau D; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada., Johnston D; Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada., Ibrahim M; Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada., Krajinovic M; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Tran TH; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Tewfik J; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Bussières JF; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Jean-Baptiste TR; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Lebel D; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada., Pecheux L; Stollery Children's Hospital, Edmonton, Alberta, Canada., Gyawali B; Stollery Children's Hospital, Edmonton, Alberta, Canada., Guilcher G; Alberta Children's Hospital, Calgary, Alberta, Canada., Riabowol G; Alberta Children's Hospital, Calgary, Alberta, Canada., Jong G'; Winnipeg Health Sciences Centre, Winnipeg, Manitoba, Canada., Staub M; Winnipeg Health Sciences Centre, Winnipeg, Manitoba, Canada., Cuvelier G; Winnipeg Health Sciences Centre, Winnipeg, Manitoba, Canada., Felton K; Jim Pattison Children's Hospital, Saskatoon, Saskatchewan, Canada., Khalaj S; Jim Pattison Children's Hospital, Saskatoon, Saskatchewan, Canada., Rieder M; London Health Sciences Centre, London, Ontario, Canada., Abuzgaia A; London Health Sciences Centre, London, Ontario, Canada., Lewis T; Hospital for Sick Children, Toronto, Ontario, Canada., Ghimire H; Hospital for Sick Children, Toronto, Ontario, Canada., Nathan P; Hospital for Sick Children, Toronto, Ontario, Canada., Goralski K; IWK Health Centre, Halifax, Nova Scotia, Canada., Kulkarni K; IWK Health Centre, Halifax, Nova Scotia, Canada., Forbrigger Z; IWK Health Centre, Halifax, Nova Scotia, Canada., Ross CJD; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Carleton BC; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.
Source: Pediatric blood & cancer [Pediatr Blood Cancer] 2026 Jun; Vol. 73 (6), pp. e70284. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer.
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British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Miao+F%22">Miao F</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Yau+D%22">Yau D</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Johnston+D%22">Johnston D</searchLink>; Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ibrahim+M%22">Ibrahim M</searchLink>; Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Krajinovic+M%22">Krajinovic M</searchLink>; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Tewfik+J%22">Tewfik J</searchLink>; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Bussières+JF%22">Bussières JF</searchLink>; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Jean-Baptiste+TR%22">Jean-Baptiste TR</searchLink>; Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Lebel+D%22">Lebel D</searchLink>; 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Jim Pattison Children's Hospital, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Khalaj+S%22">Khalaj S</searchLink>; Jim Pattison Children's Hospital, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Rieder+M%22">Rieder M</searchLink>; London Health Sciences Centre, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Abuzgaia+A%22">Abuzgaia A</searchLink>; London Health Sciences Centre, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lewis+T%22">Lewis T</searchLink>; Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ghimire+H%22">Ghimire H</searchLink>; Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nathan+P%22">Nathan P</searchLink>; Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Goralski+K%22">Goralski K</searchLink>; IWK Health Centre, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Kulkarni+K%22">Kulkarni K</searchLink>; 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Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101186624%22">Pediatric blood & cancer</searchLink> [Pediatr Blood Cancer] 2026 Jun; Vol. 73 (6), pp. e70284. <i>Date of Electronic Publication: </i>2026 Mar 26.
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