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PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade.

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Title: PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade.
Authors: Dzikowski M; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States., Pollin G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States., Gunia V; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States., Butler S; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Enkhtuul B; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States., Gavina Chavez J; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Zimmermann MT; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States., Mathison A; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States., Urrutia R; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.; Departments of Biochemistry, Biophysics, and Physiology, Medical College of Wisconsin, Milwaukee, WI, United States., Lomberk G; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.
Source: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2026 Mar 11; Vol. 14, pp. 1748541. Date of Electronic Publication: 2026 Mar 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
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  Data: PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade.
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  Data: <searchLink fieldCode="AU" term="%22Dzikowski+M%22">Dzikowski M</searchLink>; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Pollin+G%22">Pollin G</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Gunia+V%22">Gunia V</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Butler+S%22">Butler S</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Enkhtuul+B%22">Enkhtuul B</searchLink>; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Gavina+Chavez+J%22">Gavina Chavez J</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Zimmermann+MT%22">Zimmermann MT</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Mathison+A%22">Mathison A</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Urrutia+R%22">Urrutia R</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.; Departments of Biochemistry, Biophysics, and Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Lomberk+G%22">Lomberk G</searchLink>; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Surgery, Division of Research, Medical College of Wisconsin, Milwaukee, WI, United States.
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  Data: <searchLink fieldCode="JN" term="%22101630250%22">Frontiers in cell and developmental biology</searchLink> [Front Cell Dev Biol] 2026 Mar 11; Vol. 14, pp. 1748541. <i>Date of Electronic Publication: </i>2026 Mar 11 (<i>Print Publication: </i>2026).
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