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Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring.

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Bibliographic Details
Title:	Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring.
Authors:	Zhou T; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Yan J; Tianjin Medical University Cancer Institute and Hospital China., Mao G; Tianjin Medical University Cancer Institute and Hospital China., Zhang Y; Tianjin Medical University Cancer Institute and Hospital China., Shi S; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Hu T; Tianjin Medical University Cancer Institute and Hospital China., Xu J; Tianjin Medical University Cancer Institute and Hospital China., Zhang Y; Tianjin Medical University Cancer Institute and Hospital China., Ji Z; Peking University Cancer Hospital & Institute Beijing China., Fang Q; Second Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang China., Zhang Z; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Li Z; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Liu Z; Tianjin Medical University Cancer Institute and Hospital China., Wang Y; Tianjin Medical University Cancer Institute and Hospital China., Wang H; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Zhao T; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Gao S; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Wang X; Tianjin Medical University Cancer Institute and Hospital tianjin China., Yang C; Tianjin Institute of Industrial Biotechnology Tianjin, Tianjin China., Huang C; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Liu J; Fudan University Shanghai Cancer Center Shanghai, Shanghai China., Chang A; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Yang S; Penn State College of Medicine Hershey, PA United States., Yu J; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Feng Y; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Liu R; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Xie Y; Tianjin Medical University Cancer Institute and Hospital Tian jin China., Wang B; Tianjin Medical University Tianjin China., Hao J; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.
Source:	Cancer discovery [Cancer Discov] 2026 Mar 27. Date of Electronic Publication: 2026 Mar 27.
Publication Type:	Journal Article
Journal Info:	Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	2159-8290
DOI:	10.1158/2159-8290.CD-25-1627