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Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring.

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Title: Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring.
Authors: Zhou T; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Yan J; Tianjin Medical University Cancer Institute and Hospital China., Mao G; Tianjin Medical University Cancer Institute and Hospital China., Zhang Y; Tianjin Medical University Cancer Institute and Hospital China., Shi S; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Hu T; Tianjin Medical University Cancer Institute and Hospital China., Xu J; Tianjin Medical University Cancer Institute and Hospital China., Zhang Y; Tianjin Medical University Cancer Institute and Hospital China., Ji Z; Peking University Cancer Hospital & Institute Beijing China., Fang Q; Second Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang China., Zhang Z; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Li Z; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Liu Z; Tianjin Medical University Cancer Institute and Hospital China., Wang Y; Tianjin Medical University Cancer Institute and Hospital China., Wang H; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Zhao T; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Gao S; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Wang X; Tianjin Medical University Cancer Institute and Hospital tianjin China., Yang C; Tianjin Institute of Industrial Biotechnology Tianjin, Tianjin China., Huang C; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Liu J; Fudan University Shanghai Cancer Center Shanghai, Shanghai China., Chang A; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Yang S; Penn State College of Medicine Hershey, PA United States., Yu J; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Feng Y; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China., Liu R; Tianjin Medical University Cancer Institute and Hospital Tianjin China., Xie Y; Tianjin Medical University Cancer Institute and Hospital Tian jin China., Wang B; Tianjin Medical University Tianjin China., Hao J; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.
Source: Cancer discovery [Cancer Discov] 2026 Mar 27. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Mao+G%22">Mao G</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Shi+S%22">Shi S</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Hu+T%22">Hu T</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Ji+Z%22">Ji Z</searchLink>; Peking University Cancer Hospital & Institute Beijing China.<br /><searchLink fieldCode="AU" term="%22Fang+Q%22">Fang Q</searchLink>; Second Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Tianjin Medical University Cancer Institute and Hospital China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Zhao+T%22">Zhao T</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Gao+S%22">Gao S</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Tianjin Medical University Cancer Institute and Hospital tianjin China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Tianjin Institute of Industrial Biotechnology Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Fudan University Shanghai Cancer Center Shanghai, Shanghai China.<br /><searchLink fieldCode="AU" term="%22Chang+A%22">Chang A</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Penn State College of Medicine Hershey, PA United States.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin China.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tian jin China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Tianjin Medical University Tianjin China.<br /><searchLink fieldCode="AU" term="%22Hao+J%22">Hao J</searchLink>; Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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        Value: 10.1158/2159-8290.CD-25-1627
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              Text: 2026 Mar 27
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