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The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus.

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Title: The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus.
Authors: Shiota T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan., Zhao Y; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Shiota I; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan., Duyvesteyn HME; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Yamaoka M; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan., Das A; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Kapustina M; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Shah P; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Muramatsu M; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan., Wang X; State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Fry EE; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Stuart DI; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford OX3 7BN, United Kingdom., Lemon SM; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 07; Vol. 123 (14), pp. e2534261123. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Shiota+T%22">Shiota T</searchLink>; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shiota+I%22">Shiota I</searchLink>; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Duyvesteyn+HME%22">Duyvesteyn HME</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yamaoka+M%22">Yamaoka M</searchLink>; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Das+A%22">Das A</searchLink>; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Kapustina+M%22">Kapustina M</searchLink>; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Shah+P%22">Shah P</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Muramatsu+M%22">Muramatsu M</searchLink>; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe T650-0047, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Fry+EE%22">Fry EE</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stuart+DI%22">Stuart DI</searchLink>; Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lemon+SM%22">Lemon SM</searchLink>; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
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              Text: 2026 Apr 07
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