Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity.
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| Title: | Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity. |
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| Authors: | Tiberti S; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Gennari S; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Romeo M; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Sheraj I; Centre for Genomic Regulation, Barcelona, Spain., Kassir MF; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Fernández-García J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Nava Lauson CB; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Noberini R; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Catozzi C; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Dallavilla T; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Ballerini M; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy., Loffreda A; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., Codreanu SG; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Sherrod SD; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Leaptrot KL; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Schrimpe-Rutledge AC; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., McLean JA; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Schaefer MH; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Rodighiero S; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Bonaldi T; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Ogretmen B; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Sdelci S; Centre for Genomic Regulation, Barcelona, Spain., Nezi L; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Manzo T; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy. |
| Source: | Science immunology [Sci Immunol] 2026 Mar 27; Vol. 11 (117), pp. eaeb1459. Date of Electronic Publication: 2026 Mar 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.aeb1459 |
