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Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity.

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Title: Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity.
Authors: Tiberti S; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Gennari S; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Romeo M; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Sheraj I; Centre for Genomic Regulation, Barcelona, Spain., Kassir MF; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Fernández-García J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Nava Lauson CB; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Noberini R; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Catozzi C; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Dallavilla T; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Ballerini M; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy., Loffreda A; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., Codreanu SG; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Sherrod SD; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Leaptrot KL; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Schrimpe-Rutledge AC; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., McLean JA; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Schaefer MH; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Rodighiero S; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Bonaldi T; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Ogretmen B; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Sdelci S; Centre for Genomic Regulation, Barcelona, Spain., Nezi L; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy., Manzo T; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.
Source: Science immunology [Sci Immunol] 2026 Mar 27; Vol. 11 (117), pp. eaeb1459. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Tiberti+S%22">Tiberti S</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gennari+S%22">Gennari S</searchLink>; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Romeo+M%22">Romeo M</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sheraj+I%22">Sheraj I</searchLink>; Centre for Genomic Regulation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kassir+MF%22">Kassir MF</searchLink>; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Fernández-García+J%22">Fernández-García J</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Nava+Lauson+CB%22">Nava Lauson CB</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Noberini+R%22">Noberini R</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Catozzi+C%22">Catozzi C</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Dallavilla+T%22">Dallavilla T</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ballerini+M%22">Ballerini M</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Loffreda+A%22">Loffreda A</searchLink>; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Codreanu+SG%22">Codreanu SG</searchLink>; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sherrod+SD%22">Sherrod SD</searchLink>; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Leaptrot+KL%22">Leaptrot KL</searchLink>; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Schrimpe-Rutledge+AC%22">Schrimpe-Rutledge AC</searchLink>; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22McLean+JA%22">McLean JA</searchLink>; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Schaefer+MH%22">Schaefer MH</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rodighiero+S%22">Rodighiero S</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonaldi+T%22">Bonaldi T</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fendt+SM%22">Fendt SM</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ogretmen+B%22">Ogretmen B</searchLink>; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Sdelci+S%22">Sdelci S</searchLink>; Centre for Genomic Regulation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nezi+L%22">Nezi L</searchLink>; Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Manzo+T%22">Manzo T</searchLink>; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.
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