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UPR/ATF4/Noxa pathway overactivation through SERCA2 inhibition or ONC201 treatment combined with ABT-737 triggers apoptosis in chemoresistant ovarian cancer cells and patient-derived tumor organoids.

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Title: UPR/ATF4/Noxa pathway overactivation through SERCA2 inhibition or ONC201 treatment combined with ABT-737 triggers apoptosis in chemoresistant ovarian cancer cells and patient-derived tumor organoids.
Authors: Messaoudi S; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France., Florent R; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Weiswald LB; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Desmartin G; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Lecouflet L; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Lohard S; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France., Grunchec L; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France., Abeilard E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France., Guillamin M; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France., Divoux J; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France., Goudergues B; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France., Brotin E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', IMPEDANCELL Core Facility, Caen, France., Dolivet E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Department of Surgery, Caen, France., Poulain L; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France., N'Diaye M; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France. monique.ndiaye@unicaen.fr.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08559-7