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UPR/ATF4/Noxa pathway overactivation through SERCA2 inhibition or ONC201 treatment combined with ABT-737 triggers apoptosis in chemoresistant ovarian cancer cells and patient-derived tumor organoids.

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Title: UPR/ATF4/Noxa pathway overactivation through SERCA2 inhibition or ONC201 treatment combined with ABT-737 triggers apoptosis in chemoresistant ovarian cancer cells and patient-derived tumor organoids.
Authors: Messaoudi S; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France., Florent R; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Weiswald LB; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Desmartin G; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Lecouflet L; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France., Lohard S; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France., Grunchec L; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France., Abeilard E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France., Guillamin M; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France., Divoux J; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France., Goudergues B; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France., Brotin E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', IMPEDANCELL Core Facility, Caen, France., Dolivet E; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Department of Surgery, Caen, France., Poulain L; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France., N'Diaye M; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France. monique.ndiaye@unicaen.fr.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: UPR/ATF4/Noxa pathway overactivation through SERCA2 inhibition or ONC201 treatment combined with ABT-737 triggers apoptosis in chemoresistant ovarian cancer cells and patient-derived tumor organoids.
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  Data: <searchLink fieldCode="AU" term="%22Messaoudi+S%22">Messaoudi S</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Florent+R%22">Florent R</searchLink>; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.<br /><searchLink fieldCode="AU" term="%22Weiswald+LB%22">Weiswald LB</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.<br /><searchLink fieldCode="AU" term="%22Desmartin+G%22">Desmartin G</searchLink>; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.<br /><searchLink fieldCode="AU" term="%22Lecouflet+L%22">Lecouflet L</searchLink>; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.<br /><searchLink fieldCode="AU" term="%22Lohard+S%22">Lohard S</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Grunchec+L%22">Grunchec L</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Abeilard+E%22">Abeilard E</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Guillamin+M%22">Guillamin M</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France.<br /><searchLink fieldCode="AU" term="%22Divoux+J%22">Divoux J</searchLink>; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France.<br /><searchLink fieldCode="AU" term="%22Goudergues+B%22">Goudergues B</searchLink>; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.<br /><searchLink fieldCode="AU" term="%22Brotin+E%22">Brotin E</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', IMPEDANCELL Core Facility, Caen, France.<br /><searchLink fieldCode="AU" term="%22Dolivet+E%22">Dolivet E</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Department of Surgery, Caen, France.<br /><searchLink fieldCode="AU" term="%22Poulain+L%22">Poulain L</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ORGAPRED Core Facility, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', ISOCELL, Caen, France.; Université de Caen Normandie, Services Unit PLATON 'Support Platforms for Preclinical and Translational Research in Oncology', 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.; UNICANCER, Comprehensive Cancer Center F. Baclesse, 'OvaRessources' Collection of BioREVA Biological Resource Center, Caen, France.<br /><searchLink fieldCode="AU" term="%22N'Diaye+M%22">N'Diaye M</searchLink>; Université de Caen Normandie, INSERM, ANTICIPE U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Comprehensive Cancer Center F. Baclesse, Caen, France. monique.ndiaye@unicaen.fr.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Mar 27; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 27.
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