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APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction.

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Title: APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction.
Authors: Yu Q; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Du F; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.; Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA., Puerta-Alvarado V; Neurobiology and Behavior PhD Program, Columbia University, New York, NY, USA., Goodman JH; Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.; Departments of Physiology, Pharmacology, and Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Waites CL; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. cw2622@cumc.columbia.edu.; Department of Neuroscience, Columbia University, New York, NY, USA. cw2622@cumc.columbia.edu.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08543-1