Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.
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| Title: | Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy. |
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| Authors: | Hirunagi T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Nagoya University Institute for Advanced Research, Nagoya, Japan., Sahashi K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. sahashi.kentaro.r7@f.mail.nagoya-u.ac.jp., Iida M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Onodera K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan., Yokoi S; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ogura Y; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Tohnai G; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of ALS Research, Aichi Medical University, Nagakute, Japan., Sakakibara K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Maeda K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Bennett CF; Ionis Pharmaceuticals, Carlsbad, CA, USA., Okada Y; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan., Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. katsuno.masahisa.i1@f.mail.nagoya-u.ac.jp. |
| Source: | Nature communications [Nat Commun] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-70244-2 |
