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Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.

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Title: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.
Authors: Hirunagi T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Nagoya University Institute for Advanced Research, Nagoya, Japan., Sahashi K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. sahashi.kentaro.r7@f.mail.nagoya-u.ac.jp., Iida M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Onodera K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan., Yokoi S; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ogura Y; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Tohnai G; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of ALS Research, Aichi Medical University, Nagakute, Japan., Sakakibara K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Maeda K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Bennett CF; Ionis Pharmaceuticals, Carlsbad, CA, USA., Okada Y; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan., Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. katsuno.masahisa.i1@f.mail.nagoya-u.ac.jp.
Source: Nature communications [Nat Commun] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.
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  Data: <searchLink fieldCode="AU" term="%22Hirunagi+T%22">Hirunagi T</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Nagoya University Institute for Advanced Research, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Sahashi+K%22">Sahashi K</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. sahashi.kentaro.r7@f.mail.nagoya-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Iida+M%22">Iida M</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Onodera+K%22">Onodera K</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoi+S%22">Yokoi S</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Ogura+Y%22">Ogura Y</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Tohnai+G%22">Tohnai G</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of ALS Research, Aichi Medical University, Nagakute, Japan.<br /><searchLink fieldCode="AU" term="%22Sakakibara+K%22">Sakakibara K</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+K%22">Maeda K</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Bennett+CF%22">Bennett CF</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Okada+Y%22">Okada Y</searchLink>; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Japan.<br /><searchLink fieldCode="AU" term="%22Katsuno+M%22">Katsuno M</searchLink>; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. katsuno.masahisa.i1@f.mail.nagoya-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Mar 27; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 27.
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              Text: 2026 Mar 27
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