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Green diastereoselective synthesis of spiropyrrolidines by the one-pot three component reaction of isatins, THβC and 5-arylidene-thiazolidine-2,4-diones and its anticancer evaluation.

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Title: Green diastereoselective synthesis of spiropyrrolidines by the one-pot three component reaction of isatins, THβC and 5-arylidene-thiazolidine-2,4-diones and its anticancer evaluation.
Authors: Mohan M; Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India., Sudhina S; Translational Nanomedicine and Lifestyle Disease Research Laboratory, Department of Biochemistry, University of Kerala, Kariavattom campus, Thiruvananthapuram 695581, Kerala, India; Centre for Advanced Cancer Research, Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India., Meenakshy CB; Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India., Ruksana CS; Department of Chemistry, St. Michael's College, Cherthala, Alappuzha 688539, Kerala, India., Jayasree EG; Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 682022, Kerala, India., Janeesh PA; Translational Nanomedicine and Lifestyle Disease Research Laboratory, Department of Biochemistry, University of Kerala, Kariavattom campus, Thiruvananthapuram 695581, Kerala, India; Centre for Advanced Cancer Research, Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India.. Electronic address: janeeshbiochemistry@keralauniversity.ac.in., Deepthi A; Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India. Electronic address: anideepthi@gmail.com.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jul 05; Vol. 175, pp. 109786. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2120
DOI:10.1016/j.bioorg.2026.109786