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Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.

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Title: Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.
Authors: Hall A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., El-Haou S; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Villar IC; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Molla D; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Kwan M; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada., Purbrick S; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Henry D; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Kirk J; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Hawthorne G; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Canzolino S; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Harding J; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Harmer A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Bucchi A; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Roberts L; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Pointon A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Protze S; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada., Baruscotti M; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Wright L; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. Electronic address: lindsay.wright@astrazeneca.com.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Jun; Vol. 511, pp. 117804. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-0333
DOI:10.1016/j.taap.2026.117804