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Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.

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Title: Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.
Authors: Hall A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., El-Haou S; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Villar IC; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Molla D; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Kwan M; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada., Purbrick S; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Henry D; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Kirk J; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Hawthorne G; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Canzolino S; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Harding J; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom., Harmer A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Bucchi A; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Roberts L; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Pointon A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Protze S; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada., Baruscotti M; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy., Wright L; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. Electronic address: lindsay.wright@astrazeneca.com.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Jun; Vol. 511, pp. 117804. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.
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  Data: <searchLink fieldCode="AU" term="%22Hall+A%22">Hall A</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22El-Haou+S%22">El-Haou S</searchLink>; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Villar+IC%22">Villar IC</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Molla+D%22">Molla D</searchLink>; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Kwan+M%22">Kwan M</searchLink>; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Purbrick+S%22">Purbrick S</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Henry+D%22">Henry D</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kirk+J%22">Kirk J</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hawthorne+G%22">Hawthorne G</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Canzolino+S%22">Canzolino S</searchLink>; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Harding+J%22">Harding J</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harmer+A%22">Harmer A</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bucchi+A%22">Bucchi A</searchLink>; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Roberts+L%22">Roberts L</searchLink>; Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pointon+A%22">Pointon A</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Protze+S%22">Protze S</searchLink>; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Baruscotti+M%22">Baruscotti M</searchLink>; Department of Biosciences, The Cell Physiology MiLab, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Wright+L%22">Wright L</searchLink>; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. Electronic address: lindsay.wright@astrazeneca.com.
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              Text: 2026 Jun
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