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BMP4-driven morphogenetic reprogramming sustains EGFR-TKI resistance via SOX2 suppression and EMT activation.

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Title: BMP4-driven morphogenetic reprogramming sustains EGFR-TKI resistance via SOX2 suppression and EMT activation.
Authors: Chen A; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Xie DJ; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Jhu YW; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Lin YJ; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Wu DY; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Yan SL; PharmaEssentia Corporation, Taipei, Taiwan., Chou YT; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. Electronic address: ytchou@life.nthu.edu.tw., Ko JC; Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address: e1205470@ms22.hinet.net.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 May; Vol. 198, pp. 119281. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: BMP4-driven morphogenetic reprogramming sustains EGFR-TKI resistance via SOX2 suppression and EMT activation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+A%22">Chen A</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xie+DJ%22">Xie DJ</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jhu+YW%22">Jhu YW</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YJ%22">Lin YJ</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+DY%22">Wu DY</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yan+SL%22">Yan SL</searchLink>; PharmaEssentia Corporation, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+YT%22">Chou YT</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. Electronic address: ytchou@life.nthu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Ko+JC%22">Ko JC</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address: e1205470@ms22.hinet.net.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 May; Vol. 198, pp. 119281. <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biopha.2026.119281
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      – Code: eng
        Text: English
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      – TitleFull: BMP4-driven morphogenetic reprogramming sustains EGFR-TKI resistance via SOX2 suppression and EMT activation.
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            NameFull: Chen A
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            NameFull: Xie DJ
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              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
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              Value: 198
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