Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis.

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Title: Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis.
Authors: Wrønding T; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Vomstein K; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lundgaard AT; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., DeLong K; Freya Biosciences Aps, Copenhagen, Denmark., Mollerup S; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark., Mortensen B; Freya Biosciences Aps, Copenhagen, Denmark., Bosma EF; Freya Biosciences Aps, Copenhagen, Denmark., Hellerung AM; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Engel EV; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Wiil KD; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Heintz JE; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Halkjær SI; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Hugerth LW; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Hartwig TS; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Petersen AM; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Thomsen AB; Freya Biosciences Aps, Copenhagen, Denmark., Westergaard D; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., la Cour Freiesleben N; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Westh H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., van Hylckama Vlieg JET; Freya Biosciences Aps, Copenhagen, Denmark., Ensign LM; Freya Biosciences Aps, Copenhagen, Denmark; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Infectious Diseases, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Nielsen HS; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: henriette.svarre.nielsen@regionh.dk.
Source: The Lancet. Microbe [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101294. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-5247
DOI:10.1016/j.lanmic.2025.101294