Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli.

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Title: Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli.
Authors: Tigue ML; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States., Jagarlamudi R; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Chi C; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Diaz D; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Chen HC; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Sheng Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Chen SC; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Schwarzkopf A; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United States., Goettel JA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Institute of Infection, Inflammation and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States., Pua HH; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Institute of Infection, Inflammation and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Lee E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United States., Weiss VL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 12; Vol. 17, pp. 1752131. Date of Electronic Publication: 2026 Mar 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1752131