Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia.

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Title: Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia.
Authors: Levine DA; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA., Hayward RA; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA., Sussman JB; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA., Whitney RT; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA., Gałecki AT; Department of Biostatistics, U-M, Ann Arbor, MI, USA., Briceño EM; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Department of Physical Medicine and Rehabilitation, U-M, Ann Arbor, MI, USA., Gross AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Giordani BJ; Department of Psychiatry & Michigan Alzheimer's Disease Center, U-M, Ann Arbor, MI, USA., Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Gaskin DJ; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Gottesman RF; Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Yaffe K; Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, San Francisco, CA, USA., Burke JF; Department of Neurology, Ohio State College of Medicine, Columbus, OH, USA.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2026 May; Vol. 111 (1), pp. 211-221. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-8908
DOI:10.1177/13872877261430953