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Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia.

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Title: Alternative clinical trial designs to find a clinically important effect size of blood pressure-lowering on cognitive impairment and dementia.
Authors: Levine DA; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA., Hayward RA; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA., Sussman JB; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA., Whitney RT; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA., Gałecki AT; Department of Biostatistics, U-M, Ann Arbor, MI, USA., Briceño EM; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Department of Physical Medicine and Rehabilitation, U-M, Ann Arbor, MI, USA., Gross AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Giordani BJ; Department of Psychiatry & Michigan Alzheimer's Disease Center, U-M, Ann Arbor, MI, USA., Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Gaskin DJ; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Gottesman RF; Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Yaffe K; Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, San Francisco, CA, USA., Burke JF; Department of Neurology, Ohio State College of Medicine, Columbus, OH, USA.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2026 May; Vol. 111 (1), pp. 211-221. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Levine+DA%22">Levine DA</searchLink>; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hayward+RA%22">Hayward RA</searchLink>; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sussman+JB%22">Sussman JB</searchLink>; Institute for Healthcare Policy and Innovation, U-M, Ann Arbor, MI, USA.; Ann Arbor Veteran's Affairs Hospital, Center for Clinical Management and Research, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Whitney+RT%22">Whitney RT</searchLink>; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gałecki+AT%22">Gałecki AT</searchLink>; Department of Biostatistics, U-M, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Briceño+EM%22">Briceño EM</searchLink>; Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.; Department of Physical Medicine and Rehabilitation, U-M, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gross+AL%22">Gross AL</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Giordani+BJ%22">Giordani BJ</searchLink>; Department of Psychiatry & Michigan Alzheimer's Disease Center, U-M, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Elkind+MSV%22">Elkind MSV</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gaskin+DJ%22">Gaskin DJ</searchLink>; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gottesman+RF%22">Gottesman RF</searchLink>; Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sidney+S%22">Sidney S</searchLink>; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yaffe+K%22">Yaffe K</searchLink>; Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burke+JF%22">Burke JF</searchLink>; Department of Neurology, Ohio State College of Medicine, Columbus, OH, USA.
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  Data: <searchLink fieldCode="JN" term="%229814863%22">Journal of Alzheimer's disease : JAD</searchLink> [J Alzheimers Dis] 2026 May; Vol. 111 (1), pp. 211-221. <i>Date of Electronic Publication: </i>2026 Mar 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9814863 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1875-8908 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213872877%22">13872877 </searchLink><i>NLM ISO Abbreviation: </i>J Alzheimers Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 May
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