Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE.

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Title: Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE.
Authors: Kileel EM; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA., Malvestutto CD; Division of Infectious Diseases, Ohio State University Medical Center, Columbus, OH, USA., Zanni MV; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Davies-Smith E; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA., Fichtenbaum CJ; Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA., Lake JE; Department of Medicine, McGovern Medical School, Houston, TX, USA., Lo J; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Aberg JA; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martinez E; Infectious Diseases Service, Hospital Clinic and University of Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas, Institute de Salud Carlos III, Madrid, Spain., Patel K; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA., Bloomfield GS; Department of Medicine, Duke Global Health Institute and Duke Clinical Research Institute, Duke University, Durham, NC, USA., Chu SM; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Awwad A; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Diggs MR; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lu AB; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bares SH; Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA., Berrner D; Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco at Zuckerberg San Francisco General Hospital, San Francisco, CA, USA., Smieja M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Okeke NL; Department of Population Health Sciences and Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Kumar P; Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine, Washington, DC, USA., João E; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil., Currier JS; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Lu MT; Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Fox MP; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA., Brennan AT; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA., Douglas PS; Duke University Research Institute, Duke University School of Medicine, Durham, NC, USA., Grinspoon SK; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: sgrinspoon@mgh.harvard.edu., Ribaudo HJ; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA.
Source: The lancet. HIV [Lancet HIV] 2026 May; Vol. 13 (5), pp. e306-e315. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
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  Data: Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE.
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  Data: <searchLink fieldCode="AU" term="%22Kileel+EM%22">Kileel EM</searchLink>; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Malvestutto+CD%22">Malvestutto CD</searchLink>; Division of Infectious Diseases, Ohio State University Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zanni+MV%22">Zanni MV</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Davies-Smith+E%22">Davies-Smith E</searchLink>; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fichtenbaum+CJ%22">Fichtenbaum CJ</searchLink>; Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lake+JE%22">Lake JE</searchLink>; Department of Medicine, McGovern Medical School, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lo+J%22">Lo J</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aberg+JA%22">Aberg JA</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+E%22">Martinez E</searchLink>; Infectious Diseases Service, Hospital Clinic and University of Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas, Institute de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Patel+K%22">Patel K</searchLink>; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bloomfield+GS%22">Bloomfield GS</searchLink>; Department of Medicine, Duke Global Health Institute and Duke Clinical Research Institute, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chu+SM%22">Chu SM</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Awwad+A%22">Awwad A</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Diggs+MR%22">Diggs MR</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+AB%22">Lu AB</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bares+SH%22">Bares SH</searchLink>; Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Berrner+D%22">Berrner D</searchLink>; Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco at Zuckerberg San Francisco General Hospital, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Smieja+M%22">Smieja M</searchLink>; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Okeke+NL%22">Okeke NL</searchLink>; Department of Population Health Sciences and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22João+E%22">João E</searchLink>; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Currier+JS%22">Currier JS</searchLink>; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+MT%22">Lu MT</searchLink>; Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fox+MP%22">Fox MP</searchLink>; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+AT%22">Brennan AT</searchLink>; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Global Health, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Douglas+PS%22">Douglas PS</searchLink>; Duke University Research Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Grinspoon+SK%22">Grinspoon SK</searchLink>; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: sgrinspoon@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Ribaudo+HJ%22">Ribaudo HJ</searchLink>; Center for Biostatistics in AIDS Research, Harvard T H Chan School of Public Health, Boston, MA, USA.
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