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Radiofrequency Ablation and Chemotherapy vs Chemotherapy Only in Locally Advanced Pancreatic Cancer: The PELICAN Randomized Clinical Trial.

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Title: Radiofrequency Ablation and Chemotherapy vs Chemotherapy Only in Locally Advanced Pancreatic Cancer: The PELICAN Randomized Clinical Trial.
Authors: Seelen LWF; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Brada LJH; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Walma MS; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Rombouts SJE; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Braat MN; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Bollen TL; Department of Radiology, St Antonius Hospital, Nieuwegein, the Netherlands., Borel Rinkes IH; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Bruijnen RCG; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Busch OR; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., Cirkel GA; Department of Medical Oncology, Regional Academic Cancer Center Utrecht, Meander Medical Center Amersfoort, University Medical Center, Utrecht, the Netherlands., Daamen LA; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands., Daams F; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., van Dam RM; Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands., van Delden OM; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Derksen WJM; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Festen S; Department of Surgery, OLVG, Amsterdam, the Netherlands., Groothuis K; Clinical Research Department, Comprehensive Cancer Organisation the Netherlands, Nijmegen, the Netherlands., Hagendoorn J; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., de Hingh IHJT; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands., D'Hondt M; Department of Surgery, AZ Groeninge, Kortrijk, Belgium., Liem MSL; Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands., van Lienden KP; Department of Interventional Radiology, St Antonius Hospital, Nieuwegein, the Netherlands., Los M; Department of Medical Oncology, Regional Academic Cancer Center Utrecht, St Antonius Hospital Nieuwegein, University Medical Center, Utrecht, the Netherlands., de Meijer VE; Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands., Mekenkamp LJM; Department of Medical Oncology, Medisch Spectrum Twente, Enschede, the Netherlands., Nijkamp MW; Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands., Nio CY; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Cancer Center, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands., Pando E; Department of Hepato-Pancreato-Biliary and Transplant Surgery Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain., Patijn GA; Department of Surgery, Isala Clinics, Zwolle, the Netherlands., Polée MB; Department of Medical Oncology, Medical Center Leeuwarden, Leeuwarden, the Netherlands., Te Riele WW; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Roeyen G; Department of Hepato-Pancreato-Biliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium., Stommel MWJ; Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands., de Vos-Geelen J; Department of Internal Medicine, Division of Medical Oncology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, the Netherlands., de Vries JJ; Department of Radiology, OLVG, Amsterdam, the Netherlands., Wessels FJ; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Wilmink JW; Cancer Center Amsterdam, Amsterdam, the Netherlands.; Amsterdam UMC, location University of Amsterdam, Department of Medical Oncology, Amsterdam, the Netherlands., van de Ven PM; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, the Netherlands., Besselink MG; Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.; Cancer Center Amsterdam, Amsterdam, the Netherlands., van Santvoort HC; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands., Molenaar IQ; Department of Surgery, UMC Utrecht Cancer Center and St Antonius Hospital Nieuwegein, Utrecht, the Netherlands.; Regional Academic Cancer Center Utrecht, Utrecht, the Netherlands.
Corporate Authors: Dutch Pancreatic Cancer Group
Source: JAMA network open [JAMA Netw Open] 2026 Mar 02; Vol. 9 (3), pp. e263861. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2574-3805
DOI:10.1001/jamanetworkopen.2026.3861