Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system.

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Title: Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system.
Authors: Shi R; College of Chemistry, Fuzhou University, Fuzhou, China., Yang M; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Liu Y; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Gao H; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. gaohaishan@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, China. gaohaishan@westlake.edu.cn., Lin Z; College of Chemistry, Fuzhou University, Fuzhou, China. zhonghui.lin@fzu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3416-3429. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-026-00767-3