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Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system.

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Title: Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system.
Authors: Shi R; College of Chemistry, Fuzhou University, Fuzhou, China., Yang M; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Liu Y; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Gao H; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. gaohaishan@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, China. gaohaishan@westlake.edu.cn., Lin Z; College of Chemistry, Fuzhou University, Fuzhou, China. zhonghui.lin@fzu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3416-3429. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Shi+R%22">Shi R</searchLink>; College of Chemistry, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. gaohaishan@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, China. gaohaishan@westlake.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; College of Chemistry, Fuzhou University, Fuzhou, China. zhonghui.lin@fzu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 May; Vol. 45 (10), pp. 3416-3429. <i>Date of Electronic Publication: </i>2026 Mar 31.
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        Value: 10.1038/s44318-026-00767-3
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              Text: 2026 May
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