Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.

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Bibliographic Details
Title: Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.
Authors: Wu B; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Zeng W; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Tang K; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Xiong J; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Mo X; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Fu Q; Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China., Fu D; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Chu R; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Zhao G; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Lu L; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Wang Z; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Wu L; The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China., Yu Z; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China. zhqyu@21cn.com., Zhou X; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. zhou_xiangyu@fudan.edu.cn., Wang H; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Children's Hospital of Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.
Source: Cell research [Cell Res] 2026 Apr 01. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1748-7838
DOI:10.1038/s41422-026-01241-9