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Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.

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Title: Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.
Authors: Wu B; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China., Zeng W; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Tang K; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Xiong J; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Mo X; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Fu Q; Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China., Fu D; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Chu R; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China., Zhao G; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Lu L; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Wang Z; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Wu L; The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China., Yu Z; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China. zhqyu@21cn.com., Zhou X; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. zhou_xiangyu@fudan.edu.cn., Wang H; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Children's Hospital of Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.
Source: Cell research [Cell Res] 2026 Apr 01. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.
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  Data: <searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zeng+W%22">Zeng W</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tang+K%22">Tang K</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xiong+J%22">Xiong J</searchLink>; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mo+X%22">Mo X</searchLink>; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fu+Q%22">Fu Q</searchLink>; Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fu+D%22">Fu D</searchLink>; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chu+R%22">Chu R</searchLink>; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+G%22">Zhao G</searchLink>; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; The Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Eye and ENT Hospital of Fudan University, NHC Key Laboratory of Myopia, Shanghai, China. zhqyu@21cn.com.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. zhou_xiangyu@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.; Children's Hospital of Fudan University, Shanghai, China. wanghylab@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229425763%22">Cell research</searchLink> [Cell Res] 2026 Apr 01. <i>Date of Electronic Publication: </i>2026 Apr 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9425763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1748-7838 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210010602%22">10010602 </searchLink><i>NLM ISO Abbreviation: </i>Cell Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41422-026-01241-9
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              Text: 2026 Apr 01
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