Pharmacokinetic Comparability Assessment of Tixagevimab and Cilgavimab Developed for COVID-19 Prevention and Treatment Using Standard Exposure Metrics and Partial Area Under the Curve.

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Title: Pharmacokinetic Comparability Assessment of Tixagevimab and Cilgavimab Developed for COVID-19 Prevention and Treatment Using Standard Exposure Metrics and Partial Area Under the Curve.
Authors: Zhang H; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, MD, 20878, USA. huixia.zhang1@astrazeneca.com., Tang W; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Sadow S; Biometrics, Vaccines and Immune Therapies, AstraZeneca, Wilmington, DE, USA., Baronio R; Biometrics, Vaccines and Immune Therapies, R&D, AstraZeneca, Cambridge, UK., Tullio AN; Global Patient Safety, Vaccines and Immune Therapies, R&D, AstraZeneca, Gaithersburg, MD, USA., Hirao L; Clinical Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Dzutseva V; Global Patient Safety, Vaccines and Immune Therapies, R&D, AstraZeneca, Gaithersburg, MD, USA., Chen CC; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, CA, USA., Kiazand A; Global Patient Safety, Vaccines and Immune Therapies, R&D, AstraZeneca, Gaithersburg, MD, USA., Chang LJ; Clinical Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Cohen TS; Clinical Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Gibbs M; Clinical Development, Vaccines and Immune Therapies, AstraZeneca, Cambridge, UK.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 May; Vol. 65 (5), pp. 747-761. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Comparative Study
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1179-1926
DOI:10.1007/s40262-026-01631-7