Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.

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Title: Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.
Authors: Dutta A; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA., Ji JH; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Syed S; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Fang Q; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Mukhopadhyay P; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Wang H; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Loranc E; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Medina D; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Abdulsahib S; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Zhou S; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA., Tovar M; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Wang J; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Benoit JM; Nationwide Children's Hospital, Center for Childhood Cancer, Columbus, OH, USA., Liang F; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Tomimatsu N; Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Nyalwidhe JO; Department of Microbiology and Molecular Cell Biology and The Leroy T. Canoles, Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, USA., Dray E; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Verway-Cohen A; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., McDonald DT; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., de la Peña Avalos B; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA., Li W; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA., Herrero AO; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Fitzgerald O; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA., Taylor AB; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Kwon Y; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Semmes OJ; Department of Microbiology and Molecular Cell Biology and The Leroy T. Canoles, Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, USA., Tsai MS; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Rao M; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA., Hromas R; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Division of Hematology and Medical Oncology, Department of Medicine and the Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Burma S; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Chen Y; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Mazin AV; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA., Wasmuth E; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Olsen SK; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Zhou D; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA., Bishop AJR; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA. alex.bishop@nationwidechildrens.org.; Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA. alex.bishop@nationwidechildrens.org.; Nationwide Children's Hospital, Center for Childhood Cancer, Columbus, OH, USA. alex.bishop@nationwidechildrens.org., Zhao W; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA. zhaow2@uthscsa.edu.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA. zhaow2@uthscsa.edu., Kupfer GM; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. Gary.Kupfer@georgetown.edu., Sung P; Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX, USA. sungp@uthscsa.edu.; Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA. sungp@uthscsa.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 Apr; Vol. 33 (4), pp. 615-630. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-9985
DOI:10.1038/s41594-026-01778-8