Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling.
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| Title: | Stiff matrix-induced KRTAP2-3 expression suppresses ciliogenesis via actin tension-driven chromatin remodeling. |
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| Authors: | Chen X; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Yi L; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Xie G; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China., Jin H; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Yang F; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Cao W; State Key Laboratory of Industrial Control Technology, Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou, China., Shi Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Xu Z; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Li S; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Huo C; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Li Y; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China., Lin A; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China., Liu W; Metabolic Medicine Center, International Institutes of Medicine and the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China., Ou G; Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory for Protein Science, School of Life Sciences, Tsinghua University, Beijing, China., Zhou T; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. tzhou@zju.edu.cn.; Center for RNA Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China. tzhou@zju.edu.cn., Ji B; Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China. bhji@zju.edu.cn.; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. bhji@zju.edu.cn., Xie S; National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn.; Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. sxie@zju.edu.cn. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 02; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08678-1 |