Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.

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Title: Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.
Authors: Leite JA; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. jeffersonleite@micro.ufrj.br.; Department of Immunology, Institute of Microbiology Paulo de Góes, Center of Health Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. jeffersonleite@micro.ufrj.br.; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. jeffersonleite@micro.ufrj.br., Bos NN; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil., Menezes-Silva L; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Martins da Silva E; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Silva Leandro GD; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Moreira de Goes GC; Laboratory of Cheminformatics (LCi), Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil., da Silva P; Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Oliveira S; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., de Almeida Santos ES; Institute of Immunology, Rostock University Medical Center, Rostock, Germany., Ranfley H; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Palagi I; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil., Andrade-Silva M; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Ferreira CP; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Nery Neto JAO; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Yuji Yariwake V; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Cipelli M; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Leocata B; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Gonçalves T; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Gabry da Silveira A; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Baroni S; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Weiner HL; Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Hofmann TG; Institute of Toxicology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Scheu S; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil., Neves BJ; Institute of Immunology, Rostock University Medical Center, Rostock, Germany., de Souza-Pinto NC; Laboratory of Cheminformatics (LCi), Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil., Colli LM; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Waisman A; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil., Marcia Muxel S; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil., Menck CFM; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Câmara NOS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. niels@icb.usp.br.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. niels@icb.usp.br.
Source: Nature communications [Nat Commun] 2026 Apr 01; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.
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  Data: <searchLink fieldCode="AU" term="%22Leite+JA%22">Leite JA</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. jeffersonleite@micro.ufrj.br.; Department of Immunology, Institute of Microbiology Paulo de Góes, Center of Health Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. jeffersonleite@micro.ufrj.br.; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. jeffersonleite@micro.ufrj.br.<br /><searchLink fieldCode="AU" term="%22Bos+NN%22">Bos NN</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Menezes-Silva+L%22">Menezes-Silva L</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+da+Silva+E%22">Martins da Silva E</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+Leandro+GD%22">Silva Leandro GD</searchLink>; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Moreira+de+Goes+GC%22">Moreira de Goes GC</searchLink>; Laboratory of Cheminformatics (LCi), Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+P%22">da Silva P</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oliveira+S%22">Oliveira S</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+Santos+ES%22">de Almeida Santos ES</searchLink>; Institute of Immunology, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Ranfley+H%22">Ranfley H</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Palagi+I%22">Palagi I</searchLink>; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Andrade-Silva+M%22">Andrade-Silva M</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+CP%22">Ferreira CP</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nery+Neto+JAO%22">Nery Neto JAO</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Yuji+Yariwake+V%22">Yuji Yariwake V</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cipelli+M%22">Cipelli M</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Leocata+B%22">Leocata B</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+T%22">Gonçalves T</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gabry+da+Silveira+A%22">Gabry da Silveira A</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Baroni+S%22">Baroni S</searchLink>; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Weiner+HL%22">Weiner HL</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hofmann+TG%22">Hofmann TG</searchLink>; Institute of Toxicology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Scheu+S%22">Scheu S</searchLink>; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Neves+BJ%22">Neves BJ</searchLink>; Institute of Immunology, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22de+Souza-Pinto+NC%22">de Souza-Pinto NC</searchLink>; Laboratory of Cheminformatics (LCi), Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.<br /><searchLink fieldCode="AU" term="%22Colli+LM%22">Colli LM</searchLink>; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Waisman+A%22">Waisman A</searchLink>; Division of Nephrology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marcia+Muxel+S%22">Marcia Muxel S</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Menck+CFM%22">Menck CFM</searchLink>; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Câmara+NOS%22">Câmara NOS</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. niels@icb.usp.br.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. niels@icb.usp.br.
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