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Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.

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Title: Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.
Authors: Costa DG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Gee LM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Lee G; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Sales Gomez L; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Franco AC; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Vizioli MG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Valdivieso K; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Zhang LJ; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Pirius N; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Martini H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Porritt RA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Saul D; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Cavadas C; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Ebert S; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., LeBrasseur NK; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Adams CM; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Robbins PD; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Department of Neurology, Manyo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1530-1550. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00400-0