View in EDS HTML Full Text PDF Full Text

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.

Saved in:
Bibliographic Details
Title: Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.
Authors: Costa DG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Gee LM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Lee G; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Sales Gomez L; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Franco AC; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Vizioli MG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Valdivieso K; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Zhang LJ; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Pirius N; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Martini H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Porritt RA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Saul D; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Cavadas C; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Ebert S; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., LeBrasseur NK; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Adams CM; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Robbins PD; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Department of Neurology, Manyo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1530-1550. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41922652
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Costa+DG%22">Costa DG</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Gee+LM%22">Gee LM</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Lee+G%22">Lee G</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Sales+Gomez+L%22">Sales Gomez L</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Franco+AC%22">Franco AC</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Vizioli+MG%22">Vizioli MG</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Valdivieso+K%22">Valdivieso K</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+LJ%22">Zhang LJ</searchLink>; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pirius+N%22">Pirius N</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Martini+H%22">Martini H</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Porritt+RA%22">Porritt RA</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saul+D%22">Saul D</searchLink>; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Cavadas+C%22">Cavadas C</searchLink>; Center for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Ebert+S%22">Ebert S</searchLink>; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22LeBrasseur+NK%22">LeBrasseur NK</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Passos+JF%22">Passos JF</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Adams+CM%22">Adams CM</searchLink>; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jurk+D%22">Jurk D</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.; Department of Neurology, Manyo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1530-1550. <i>Date of Electronic Publication: </i>2026 Apr 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41922652
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44321-026-00400-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1530
    Titles:
      – TitleFull: Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Costa DG
      – PersonEntity:
          Name:
            NameFull: Gee LM
      – PersonEntity:
          Name:
            NameFull: Lee G
      – PersonEntity:
          Name:
            NameFull: Sales Gomez L
      – PersonEntity:
          Name:
            NameFull: Franco AC
      – PersonEntity:
          Name:
            NameFull: Vizioli MG
      – PersonEntity:
          Name:
            NameFull: Valdivieso K
      – PersonEntity:
          Name:
            NameFull: Zhang LJ
      – PersonEntity:
          Name:
            NameFull: Pirius N
      – PersonEntity:
          Name:
            NameFull: Martini H
      – PersonEntity:
          Name:
            NameFull: Porritt RA
      – PersonEntity:
          Name:
            NameFull: Saul D
      – PersonEntity:
          Name:
            NameFull: Cavadas C
      – PersonEntity:
          Name:
            NameFull: Ebert S
      – PersonEntity:
          Name:
            NameFull: LeBrasseur NK
      – PersonEntity:
          Name:
            NameFull: Khosla S
      – PersonEntity:
          Name:
            NameFull: Passos JF
      – PersonEntity:
          Name:
            NameFull: Adams CM
      – PersonEntity:
          Name:
            NameFull: Robbins PD
      – PersonEntity:
          Name:
            NameFull: Jurk D
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1757-4684
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: EMBO molecular medicine
              Type: main
ResultId 1