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FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.

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Title: FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.
Authors: Liu J; Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China.; Precision Oncology Medicine Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China., Xiao T; Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China.; Precision Oncology Medicine Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China., Huang J; Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China. huangjun@email.ncu.edu.cn.; Precision Oncology Medicine Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, PR China. huangjun@email.ncu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 Apr 01; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08056-7