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Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment.

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Title: Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment.
Authors: Yeo YY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Qiu H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Bai Y; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Chemistry, Stanford University, Stanford, CA, USA., Zhu B; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA., Chang Y; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA., Iannelli F; Division of Haematopathology, European Institute of Oncology IRCCS, Milan, Italy., Yiu SPT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Yeung J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Michel HA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Wang Y; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wang Y; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wu W; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wright K; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shaban M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Sadigh S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Nkosi D; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Shanmugam V; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rock P; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Cramer P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Paczkowska J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Stephan P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Université de Paris, Assistance Publique-Hôpitaux de Paris, Hemato-oncologie, Saint-Louis Hôspital, Paris, France., Liao G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Huang AY; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang H; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen H; Department of Pathology, Stanford University, Stanford, CA, USA., Frauenfeld L; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany., Kaufmann L; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany., Pileri S; Division of Haematopathology, European Institute of Oncology IRCCS, Milan, Italy., Mitra B; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Gewurz BE; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Zhao B; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Nolan GP; Department of Pathology, Stanford University, Stanford, CA, USA., Zhang B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Shalek AK; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Angelo M; Department of Pathology, Stanford University, Stanford, CA, USA., Schürch CM; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Mahmood F; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Chiarle R; Division of Haematopathology, European Institute of Oncology IRCCS, Milan, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Ma Q; Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA; Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA., Burack WR; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Shipp MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jiang S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: sjiang3@bidmc.harvard.edu.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Apr 21; Vol. 7 (4), pp. 102722. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment.
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  Data: <searchLink fieldCode="AU" term="%22Yeo+YY%22">Yeo YY</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Chemistry, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+Y%22">Chang Y</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 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