Saikosaponin-d attenuates postpartum estrogen withdrawal-induced depressive symptoms by modulating glucocorticoid metabolism and inhibiting hippocampal NLRP3 inflammatory vesicle activation.
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| Title: | Saikosaponin-d attenuates postpartum estrogen withdrawal-induced depressive symptoms by modulating glucocorticoid metabolism and inhibiting hippocampal NLRP3 inflammatory vesicle activation. |
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| Authors: | Zhai X; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue, Wuhan, 430022, People's Republic Of China. zhaixuejia@hust.edu.cn., Yang Q; School of Pharmacy, Hubei University of Chinese Medicine, 430065, Wuhan, People's Republic Of China., Zhao Y; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic Of China., Zeng X; School of Pharmacy, Hubei University of Chinese Medicine, 430065, Wuhan, People's Republic Of China., He Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue, Wuhan, 430022, People's Republic Of China., You Q; Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic Of China.; Hubei Shizhen Laboratory, 430065, Wuhan , People's Republic Of China. |
| Source: | Metabolic brain disease [Metab Brain Dis] 2026 Apr 02; Vol. 41 (1). Date of Electronic Publication: 2026 Apr 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41925791 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Saikosaponin-d attenuates postpartum estrogen withdrawal-induced depressive symptoms by modulating glucocorticoid metabolism and inhibiting hippocampal NLRP3 inflammatory vesicle activation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Zhai+X%22">Zhai X</searchLink>; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue, Wuhan, 430022, People's Republic Of China. zhaixuejia@hust.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; School of Pharmacy, Hubei University of Chinese Medicine, 430065, Wuhan, People's Republic Of China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic Of China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; School of Pharmacy, Hubei University of Chinese Medicine, 430065, Wuhan, People's Republic Of China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue, Wuhan, 430022, People's Republic Of China.<br /><searchLink fieldCode="AU" term="%22You+Q%22">You Q</searchLink>; Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic Of China.; Hubei Shizhen Laboratory, 430065, Wuhan , People's Republic Of China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228610370%22">Metabolic brain disease</searchLink> [Metab Brain Dis] 2026 Apr 02; Vol. 41 (1). <i>Date of Electronic Publication: </i>2026 Apr 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8610370 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7365 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208857490%22">08857490 </searchLink><i>NLM ISO Abbreviation: </i>Metab Brain Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41925791 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11011-026-01841-9 Languages: – Code: eng Text: English Titles: – TitleFull: Saikosaponin-d attenuates postpartum estrogen withdrawal-induced depressive symptoms by modulating glucocorticoid metabolism and inhibiting hippocampal NLRP3 inflammatory vesicle activation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zhai X – PersonEntity: Name: NameFull: Yang Q – PersonEntity: Name: NameFull: Zhao Y – PersonEntity: Name: NameFull: Zeng X – PersonEntity: Name: NameFull: He Y – PersonEntity: Name: NameFull: You Q IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: 2026 Apr 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1573-7365 Numbering: – Type: volume Value: 41 – Type: issue Value: 1 Titles: – TitleFull: Metabolic brain disease Type: main |
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