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The pyrazolo[3,4-d]pyrimidine derivative CLM24 has an antineoplastic effect in aggressive dedifferentiated thyroid cancer in vitro.

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Title: The pyrazolo[3,4-d]pyrimidine derivative CLM24 has an antineoplastic effect in aggressive dedifferentiated thyroid cancer in vitro.
Authors: Ferrari SM; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Ragusa F; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Elia G; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Mazzi V; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Balestri E; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Botrini C; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Rugani L; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Piaggi S; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy., La Motta C; Department of Pharmacy, University of Pisa, Pisa, 56126, Italy., Antonelli G; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Ulisse S; Department of Surgery, 'Sapienza' University of Rome, Rome, 00161, Italy., Virili C; Department of Medico-Surgical Sciences and Biotechnologies, Endocrinology Section, 'Sapienza' University of Rome, Latina, 04100, Italy., Varricchi G; Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO), Center of Excellence, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy., Cantini G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 50139, Italy., Fabrazzo O; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Romizi EC; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Martino MG; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Luconi M; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 50139, Italy., Materazzi G; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy., Antonelli A; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy. alessandro.antonelli@unipi.it., Fallahi P; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy.
Source: Endocrine [Endocrine] 2026 Apr 02; Vol. 91 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The pyrazolo[3,4-d]pyrimidine derivative CLM24 has an antineoplastic effect in aggressive dedifferentiated thyroid cancer in vitro.
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  Data: <searchLink fieldCode="AU" term="%22Ferrari+SM%22">Ferrari SM</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Ragusa+F%22">Ragusa F</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Elia+G%22">Elia G</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzi+V%22">Mazzi V</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Balestri+E%22">Balestri E</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Botrini+C%22">Botrini C</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Rugani+L%22">Rugani L</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Piaggi+S%22">Piaggi S</searchLink>; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22La+Motta+C%22">La Motta C</searchLink>; Department of Pharmacy, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Antonelli+G%22">Antonelli G</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Ulisse+S%22">Ulisse S</searchLink>; Department of Surgery, 'Sapienza' University of Rome, Rome, 00161, Italy.<br /><searchLink fieldCode="AU" term="%22Virili+C%22">Virili C</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Endocrinology Section, 'Sapienza' University of Rome, Latina, 04100, Italy.<br /><searchLink fieldCode="AU" term="%22Varricchi+G%22">Varricchi G</searchLink>; Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO), Center of Excellence, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cantini+G%22">Cantini G</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 50139, Italy.<br /><searchLink fieldCode="AU" term="%22Fabrazzo+O%22">Fabrazzo O</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Romizi+EC%22">Romizi EC</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+MG%22">Martino MG</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Luconi+M%22">Luconi M</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 50139, Italy.<br /><searchLink fieldCode="AU" term="%22Materazzi+G%22">Materazzi G</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy.<br /><searchLink fieldCode="AU" term="%22Antonelli+A%22">Antonelli A</searchLink>; Department of Surgery, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, 56126, Italy. alessandro.antonelli@unipi.it.<br /><searchLink fieldCode="AU" term="%22Fallahi+P%22">Fallahi P</searchLink>; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy.
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  Data: <searchLink fieldCode="JN" term="%229434444%22">Endocrine</searchLink> [Endocrine] 2026 Apr 02; Vol. 91 (1). <i>Date of Electronic Publication: </i>2026 Apr 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9434444 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-0100 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221355008X%22">1355008X </searchLink><i>NLM ISO Abbreviation: </i>Endocrine <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 02
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