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Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.

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Title: Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.
Authors: Huang D; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China., Zhang X; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China., Wang X; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangdong, China., Huang Z; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Zeng J; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Liu X; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Tan L; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Zhang L; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Guo Z; School of Data Science, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, Guangdong, China., Gin T; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China., Yu J; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Ho KM; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan MTV; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. mtvchan@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. mtvchan@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. mtvchan@cuhk.edu.hk., Chen H; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. hchen2@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk., Wu WKK; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. wukakei@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.
Source: Oncogene [Oncogene] 2026 May; Vol. 45 (17), pp. 1600-1612. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.
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  Data: <searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; 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CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ho+KM%22">Ho KM</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+MTV%22">Chan MTV</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. mtvchan@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. mtvchan@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. mtvchan@cuhk.edu.hk.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. hchen2@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. hchen2@cuhk.edu.hk.<br /><searchLink fieldCode="AU" term="%22Wu+WKK%22">Wu WKK</searchLink>; Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.; CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China. wukakei@cuhk.edu.hk.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. wukakei@cuhk.edu.hk.
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        Value: 10.1038/s41388-026-03761-5
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        Text: English
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              Text: 2026 May
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