CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species.
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| Title: | CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species. |
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| Authors: | Kempynck N; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., De Winter S; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Blaauw CH; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Utrecht, the Netherlands., Konstantakos V; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Ekşi EC; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Dieltiens S; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Abaffyová D; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Bercier V; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Neurosciences, KU Leuven, Leuven, Belgium., Taskiran II; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Illumina Artificial Intelligence Laboratory, Illumina, Foster City, CA, USA., Hulselmans G; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Spanier K; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Christiaens V; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Van Den Bosch L; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Neurosciences, KU Leuven, Leuven, Belgium., Mahieu L; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Aerts S; Laboratory of Computational Biology, VIB Center for AI and Computational Biology (VIB.AI), Leuven, Belgium. stein.aerts@kuleuven.be.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. stein.aerts@kuleuven.be.; Department of Human Genetics, KU Leuven, Leuven, Belgium. stein.aerts@kuleuven.be.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. stein.aerts@kuleuven.be. |
| Source: | Nature methods [Nat Methods] 2026 May; Vol. 23 (5), pp. 946-959. Date of Electronic Publication: 2026 Apr 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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