Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates.
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| Title: | Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates. |
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| Authors: | Cai T; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Li Z; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Yan Q; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Huang G; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Jia K; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Chen X; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Dun J; Analytical Applications Center, Shimadzu (China) Co., Ltd., Shanghai, China., Zou J; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Tan M; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Wu Y; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Wang F; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China. fan.wang@beonemed.com. |
| Source: | The AAPS journal [AAPS J] 2026 Apr 03; Vol. 28 (3). Date of Electronic Publication: 2026 Apr 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41927976 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Cai+T%22">Cai T</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yan+Q%22">Yan Q</searchLink>; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Huang+G%22">Huang G</searchLink>; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jia+K%22">Jia K</searchLink>; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Dun+J%22">Dun J</searchLink>; Analytical Applications Center, Shimadzu (China) Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zou+J%22">Zou J</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tan+M%22">Tan M</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China. fan.wang@beonemed.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 Apr 03; Vol. 28 (3). <i>Date of Electronic Publication: </i>2026 Apr 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41927976 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1208/s12248-026-01235-w Languages: – Code: eng Text: English Titles: – TitleFull: Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cai T – PersonEntity: Name: NameFull: Li Z – PersonEntity: Name: NameFull: Yan Q – PersonEntity: Name: NameFull: Huang G – PersonEntity: Name: NameFull: Jia K – PersonEntity: Name: NameFull: Chen X – PersonEntity: Name: NameFull: Dun J – PersonEntity: Name: NameFull: Zou J – PersonEntity: Name: NameFull: Tan M – PersonEntity: Name: NameFull: Wu Y – PersonEntity: Name: NameFull: Wang F IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 04 Text: 2026 Apr 03 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1550-7416 Numbering: – Type: volume Value: 28 – Type: issue Value: 3 Titles: – TitleFull: The AAPS journal Type: main |
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