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Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates.

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Title:	Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody-Drug Conjugates.
Authors:	Cai T; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Li Z; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Yan Q; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Huang G; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Jia K; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Chen X; Department of In Vivo Pharmacology, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Dun J; Analytical Applications Center, Shimadzu (China) Co., Ltd., Shanghai, China., Zou J; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Tan M; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Wu Y; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China., Wang F; Department of DMPK-BA, BeOne Medicines (Beijing) Co., Ltd., Beijing, China. fan.wang@beonemed.com.
Source:	The AAPS journal [AAPS J] 2026 Apr 03; Vol. 28 (3). Date of Electronic Publication: 2026 Apr 03.
Publication Type:	Journal Article
Journal Info:	Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1550-7416
DOI:	10.1208/s12248-026-01235-w