A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems.
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| Title: | A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems. |
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| Authors: | Migur A; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.; Botnar Institute of Immune Engineering, Basel, Switzerland., Feussner M; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany., Liao C; Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China.; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Alkhnbashi OS; Center for Applied and Translational Genomics (CATG), Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates., Chauvier A; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA., Walter NG; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA., Backofen R; Universität Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany., Weinberg Z; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@immune.engineering.; Botnar Institute of Immune Engineering, Basel, Switzerland. chase.beisel@immune.engineering.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@immune.engineering. |
| Source: | The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3396-3415. Date of Electronic Publication: 2026 Apr 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00769-1 |
