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A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems.

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Title: A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems.
Authors: Migur A; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.; Botnar Institute of Immune Engineering, Basel, Switzerland., Feussner M; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany., Liao C; Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China.; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Alkhnbashi OS; Center for Applied and Translational Genomics (CATG), Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates., Chauvier A; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA., Walter NG; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA., Backofen R; Universität Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany., Weinberg Z; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@immune.engineering.; Botnar Institute of Immune Engineering, Basel, Switzerland. chase.beisel@immune.engineering.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@immune.engineering.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3396-3415. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems.
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  Data: <searchLink fieldCode="AU" term="%22Migur+A%22">Migur A</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.; Botnar Institute of Immune Engineering, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Feussner+M%22">Feussner M</searchLink>; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Liao+C%22">Liao C</searchLink>; Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China.; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Alkhnbashi+OS%22">Alkhnbashi OS</searchLink>; Center for Applied and Translational Genomics (CATG), Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Healthcare City, Dubai, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Chauvier+A%22">Chauvier A</searchLink>; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA.<br /><searchLink fieldCode="AU" term="%22Walter+NG%22">Walter NG</searchLink>; Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, USA.<br /><searchLink fieldCode="AU" term="%22Backofen+R%22">Backofen R</searchLink>; Universität Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weinberg+Z%22">Weinberg Z</searchLink>; Bioinformatics Group, Department of Computer Science and Interdisciplinary Centre for Bioinformatics, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Beisel+CL%22">Beisel CL</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@immune.engineering.; Botnar Institute of Immune Engineering, Basel, Switzerland. chase.beisel@immune.engineering.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@immune.engineering.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 May; Vol. 45 (10), pp. 3396-3415. <i>Date of Electronic Publication: </i>2026 Apr 02.
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              Text: 2026 May
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