Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types.
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| Title: | Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types. |
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| Authors: | Zhang M; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada., Kim YW; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada., Yang CX; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada., Gauvreau GM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., FitzGerald JM; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Boulet LP; Centre de Pneumologie de L'Hopital, Université Laval, Québec City, Québec, Canada., O'Byrne PM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Tebbutt SJ; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; PROOF Centre of Excellence, Vancouver, British Columbia, Canada., Singh A; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada. |
| Source: | PLoS computational biology [PLoS Comput Biol] 2026 Apr 03; Vol. 22 (4), pp. e1014081. Date of Electronic Publication: 2026 Apr 03 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7358 |
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| DOI: | 10.1371/journal.pcbi.1014081 |
