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Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types.

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Title: Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types.
Authors: Zhang M; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada., Kim YW; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada., Yang CX; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada., Gauvreau GM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., FitzGerald JM; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Boulet LP; Centre de Pneumologie de L'Hopital, Université Laval, Québec City, Québec, Canada., O'Byrne PM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Tebbutt SJ; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; PROOF Centre of Excellence, Vancouver, British Columbia, Canada., Singh A; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.
Source: PLoS computational biology [PLoS Comput Biol] 2026 Apr 03; Vol. 22 (4), pp. e1014081. Date of Electronic Publication: 2026 Apr 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+YW%22">Kim YW</searchLink>; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+CX%22">Yang CX</searchLink>; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Gauvreau+GM%22">Gauvreau GM</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22FitzGerald+JM%22">FitzGerald JM</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Boulet+LP%22">Boulet LP</searchLink>; Centre de Pneumologie de L'Hopital, Université Laval, Québec City, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22O'Byrne+PM%22">O'Byrne PM</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tebbutt+SJ%22">Tebbutt SJ</searchLink>; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; PROOF Centre of Excellence, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Singh+A%22">Singh A</searchLink>; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.; Providence Research, Providence Health Care, Vancouver, British Columbia, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101238922%22">PLoS computational biology</searchLink> [PLoS Comput Biol] 2026 Apr 03; Vol. 22 (4), pp. e1014081. <i>Date of Electronic Publication: </i>2026 Apr 03 (<i>Print Publication: </i>2026).
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              Text: 2026 Apr 03
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