Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance.
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| Title: | Targeting IP |
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| Authors: | Lee SG; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea.; Cas Cure Therapeutics, Magokjungang-ro 8 gil, Gangseo-gu, Seoul, Korea., Seo Y; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jeong S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Chung Y; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Kong S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kim M; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Rhlee JH; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Um S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea., Mathew BP; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Maiti S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kuram MR; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Abozeid MA; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Park A; Korea Research Institute of Chemical Technology, Daejeon, Korea., Yoo JN; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea., Khim KW; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea., Son K; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Amarsanaa E; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Kim K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea., Hong S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea., Choi J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea., Park IB; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Korea Mouse Pheotyping Center, Seoul National University, Seoul, Korea., Lee EA; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea., Jeon JH; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Park JH; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; College of Veterinary Medicine, Jeonbuk ational University, Iksan, Jeonbuk, Korea., Han JS; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Neuracle Genetics, Sanhakgwan 4F, 145 Anam-ro, Seongbuk-gu, Seoul, Korea., Park CY; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea., Kim S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.; KAIST Stem Cell Center, KAIST, Daejeon, Korea., Choi JH; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Biological Science, Ulsan National Institute of Science and Technology, Ulsan, Korea., Hong SY; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea., Seo MD; Department of Molecular Science and Technology & College of Pharmacy, Ajou University, Suwon, Korea., Lee H; Korea Research Institute of Chemical Technology, Daejeon, Korea., Lee JY; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea. leejooyong@cnu.ac.kr., Myung K; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. kmyung@ibs.re.kr.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea. kmyung@ibs.re.kr. |
| Source: | Nature communications [Nat Commun] 2026 Apr 04; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-71421-z |
